BT8001 - BIOPHYSICS (Syllabus) 2017-regulation Anna University

BT8001 - BIOPHYSICS (Syllabus) 2017-regulation Anna University

BT8001	BIOPHYSICS	LPTC

3003

OBJECTIVES:

To enable the students • To gain structural knowledge of biological systems. • To understand transport and dynamic properties of biological systems.

UNIT I	MOLECULAR STRUCTURE OF BIOLOGICAL SYSTEMS	9

Intramolecular bonds – covalent – ionic and hydrogen bonds – biological structures –general features – water structure – hydration – interfacial phenomena and membranes – self assembly and molecular structure of membranes.

UNIT II	CONFORMATION OF NUCLEIC ACIDS	9

Primary structure – the bases – sugars and the phosphodiester bonds- double helical structure – the a b and z forms – properties of circular DNA – topology – polymorphism and flexibility of DNA – structure of ribonucleic acids – hydration of nucleic acids.

UNIT III	CONFORMATION OF PROTEINS	9

Conformation of the peptide bond – secondary structures – Ramachandran plots – use of potential functions – tertiary structure – folding – hydration of proteins – hydropathy index.

UNIT IV	CELLULAR PERMEABILITY AND ION – TRANSPORT	9

Ionic conductivity – transport across ion channels – mechanism - ion pumps- proton transfer – nerve conduction – techniques of studying ion transport and models.

UNIT V	ENERGETICS & DYNAMICS OF BIOLOGICAL SYSTEMS	9

Concepts in thermodynamics – force and motion – entropy and stability – analyses of fluxes – diffusion potential – basic properties of fluids and biomaterials – laminar and turbulent flows.

TOTAL : 45 PERIODS

OUTCOMES: Upon completion of this course, students will be able:

• To analyze the various forces responsible for biological molecular structure.
• To be familiar with different levels of conformation in biomolecules.
• To gain the knowledge of cellular permeability and ion transport.
• To understand the dynamics of biological systems.

TEXT BOOKS:

1. Biophysics ; R. Glaser, Springer Verlag , 2000.
2. Biophysics: Molecules In Motion ; R. Duane. Academic Press , 1999

REFERENCE:

1. Cantror, Charles R. and Paul R. Schimmel “Biophysical Chemistry” . 1-3 Vols. W.H.Freeman & Co.,1980.