BT8006 - SYSTEMS BIOLOGY (Syllabus) 2017-regulation Anna University
BT8006 - SYSTEMS BIOLOGY (Syllabus) 2017-regulation Anna University
BT8006 | SYSTEMS BIOLOGY | LPTC |
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3003
UNIT I | INTRODUCTION | 9 |
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Introduction to Systems Biology, Systems level understanding of biological systems. Basic concepts in Systems modeling: Model Scope, Model Statements, System state, Variables, parameters and constants, Model behavior, classification and steady state. Merits of computational modeling.
UNIT II | KINETIC MODELING | 9 |
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Kinetic modeling of biochemical reactions, describing dynamics with ODEs, rate equations, deriving a rate equation, incorporating regulation of enzyme activity by effectors, E-cell platform and erythrocyte modeling.
UNIT III | FLUX BALANCE ANALYSIS | 9 |
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Introduction to Flux balance analysis, Construction of stoichiometric matrices, Constraint based models. Network basics, examples of mathematical reconstruction of transcriptional networks and signal transduction networks.
UNIT IV | NETWORK MOTIFS AND MODELS | 9 |
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Network motifs, Feed forward loop network motif. Gene circuits, robustness of models, Chemotaxis model, Integration of data from multiple sources: Building genome scale models.
UNIT V | RESOURCES AND SBML | 9 |
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Tools and databases for modeling: Pathway databases KEGG, EMP, Metacyc, Enzyme kinetics database BRENDA, Gene expression databases, Biomodels database, Basics of Systems Biology Markup Language (SBML), SBML editors.
TOTAL : 45 PERIODS
TEXT BOOKS:
1. Edda Klipp, Wolfram Liebermeister, Christoph Wierling ,Systems Biology a Textbook by Wiley-BlackWell Publications (2009 Edition).
2. Uri Alon , An introduction to Systems Biology: Design Principles of Biological Circuits, (Chapman and Hall / CRC 2007 Edition)
3. Edda Klipp, Ralf Herwig, Axel kowald, Christoph Wierling, Hans Lehrach ,Systems Biology in practice: concepts, implementation and application. (Wiley – VCH 2005)
2. Uri Alon , An introduction to Systems Biology: Design Principles of Biological Circuits, (Chapman and Hall / CRC 2007 Edition)
3. Edda Klipp, Ralf Herwig, Axel kowald, Christoph Wierling, Hans Lehrach ,Systems Biology in practice: concepts, implementation and application. (Wiley – VCH 2005)
REFERENCES:
1. Foundations of Systems Biology Edited by Hiroaki Kitano (MIT Press)
2. Systems Biology: Definitions and perspectives by Lilia Albhergina (Springer Publications 2008)
2. Systems Biology: Definitions and perspectives by Lilia Albhergina (Springer Publications 2008)
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