BT8006 - SYSTEMS BIOLOGY (Syllabus) 2017-regulation Anna University

BT8006 - SYSTEMS BIOLOGY (Syllabus) 2017-regulation Anna University

BT8006

SYSTEMS BIOLOGY

 LPTC
3003

UNIT I

INTRODUCTION

9
Introduction to Systems Biology, Systems level understanding of biological systems. Basic concepts in Systems modeling: Model Scope, Model Statements, System state, Variables, parameters and constants, Model behavior, classification and steady state. Merits of computational modeling.

UNIT II

KINETIC MODELING

9
Kinetic modeling of biochemical reactions, describing dynamics with ODEs, rate equations, deriving a rate equation, incorporating regulation of enzyme activity by effectors, E-cell platform and erythrocyte modeling.


UNIT III

FLUX BALANCE ANALYSIS

9
Introduction to Flux balance analysis, Construction of stoichiometric matrices, Constraint based models. Network basics, examples of mathematical reconstruction of transcriptional networks and signal transduction networks.

UNIT IV

NETWORK MOTIFS AND MODELS

9
Network motifs, Feed forward loop network motif. Gene circuits, robustness of models, Chemotaxis model, Integration of data from multiple sources: Building genome scale models.

UNIT V

RESOURCES AND SBML

9
Tools and databases for modeling: Pathway databases KEGG, EMP, Metacyc, Enzyme kinetics database BRENDA, Gene expression databases, Biomodels database, Basics of Systems Biology Markup Language (SBML), SBML editors.

TOTAL : 45 PERIODS

TEXT BOOKS:
1. Edda Klipp, Wolfram Liebermeister, Christoph Wierling ,Systems Biology a Textbook by Wiley-BlackWell Publications (2009 Edition).
2. Uri Alon , An introduction to Systems Biology: Design Principles of Biological Circuits, (Chapman and Hall / CRC 2007 Edition)
3. Edda Klipp, Ralf Herwig, Axel kowald, Christoph Wierling, Hans Lehrach ,Systems Biology in practice: concepts, implementation and application. (Wiley – VCH 2005)

REFERENCES:
1. Foundations of Systems Biology Edited by Hiroaki Kitano (MIT Press)
2. Systems Biology: Definitions and perspectives by Lilia Albhergina (Springer Publications 2008)
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