BT8013 - METABOLIC ENGINEERING (Syllabus) 2017-regulation Anna University

BT8013 - METABOLIC ENGINEERING (Syllabus) 2017-regulation Anna University

BT8013

METABOLIC ENGINEERING

 LPTC
3003

OBJECTIVES:
• To provide a quantitative basis, based on thermodynamics, enzyme kinetics, for the understanding of metabolic networks in single cells and at the organ level.
• To enable the students to use organisms to produce valuable substances on an industrial scale in cost effective manner.

UNIT I

INTRODUCTION TO EXAMPLES OF PATHWAY MANIPULATION - QUALITATIVE TREATMENT

9
Enhancement of Product Yield and Productivity, Extension of substrate Range, Extension of Product spectrum and Novel products, Improvement of Cellular properties, Xenobiotic degradation.

UNIT II

MATERIAL BALANCES AND DATA CONSISTENCY

9
Comprehensive models of cellular reactions; stoichiometry of cellular reactions, reaction rates, dynamic mass balances, yield coefficients and linear rate equations, analysis of over determined systems- identification of gross measurement errors. Introduction to MATLAB®


UNIT III

METABOLIC FLUX ANALYSIS

9
Theory, overdetermined systems, underdetermined systems- linear programming, sensitivity analysis, methods for the experimental determination of metabolic fluxes by isotope labeling, applications of metabolic flux analysis.

UNIT IV

METABOLIC CONTROL ANALYSIS

9
Fundamentals of Metabolic Control Analysis, control coefficients and the summation theorems, Determination of flux control coefficients, MCA of linear pathways, branched pathways, theory of large deviations

UNIT V

ANALYSIS OF METABOLIC NETWORKS

9
Control of flux distribution at a single branch point, Grouping of reactions, case studies, extension of control analysis to intermetabolite, optimization of flux amplifications, consistencytests and experimental validation.

TOTAL : 45 PERIODS

OUTCOMES: After completion of metabolic engineering, students will be able
• To learn stoichiometry and energetics of metabolism.
• To apply practical applications of metabolic engineering in chemical,energy,medical and environmental fields.
• To integrate modern biology with engineering principles.
• To design a system, component, or process to meet desired needs.

TEXT BOOKS:
1. Gregory N. Stephanopoulos ,Aristos A. Aristidou, Jens Nielsen, Metabolic Engineering: Principles and Methodologies ,Academic Press 1998.
2. Sang Yup Lee E. Terry Papoutsakis Marcel Dekker, Metabolic Engineering.inc 1998
3. Nielsen J and Villadsen J. (1994) Bioreaction Engineering Principles. New york: Plenum Press

REFERENCES:
1. Computational Analysis of Biochemical Systems: A Practical Guide for Biochemists and Molecular Biologists by Eberhard O. Voit Cambridge University Press 2000
2. Applications of Plant Metabolic Engineering. R. Verpoorte, A. W. Alfermann and T. S. Johnson (eds). Springer, P.O. Box 17, 3300 AA Dordrecht, The Netherlands. 2007.
3. Systems Modeling in Cellular Biology: From Concepts to Nuts and Bolts Edited by Zoltan Szallasi, JorgStelling and VipulPeriwal MIT Press Cambridge 2006
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