BT8023 - TISSUE ENGINEERING (Syllabus) 2017-regulation Anna University

BT8023 - TISSUE ENGINEERING (Syllabus) 2017-regulation Anna University

BT8023

TISSUE ENGINEERING

 LPTC

3003

OBJECTIVES:
To enable the students • To learn the fundamentals of tissue engineering and tissue repairing • To acquire knowledge on clinical applications of tissue engineering • To understand the basic concept behind tissue engineering focusing on the stem cells, biomaterials and its applications

UNIT I

INTRODUCTION

9

Introduction to tissue engineering: Basic definition; current scope of development; use in therapeutics, cells as therapeutic agents, cell numbers and growth rates, measurement of cell characteristics morphology, number viability, motility and functions. Measurement of tissue characteristics ,appearance, cellular component, ECM component, mechanical measurements and physical properties.

UNIT II

TISSUE ARCHITECTURE

9

Tissue types and Tissue components, Tissue repair, Engineering wound healing and sequence of events. Basic wound healing Applications of growth factors: VEGF/angiogenesis, Basic properties, Cell-Matrix& Cell-Cell Interactions, telomeres and Self-renewal, Control of cell migration in tissue engineering.


UNIT III

BIOMATERIALS

9

Biomaterials: Properties of biomaterials ,Surface, bulk, mechanical and biological properties. Scaffolds & tissue engineering, Types of biomaterials, biological and synthetic materials, Biopolymers, Applications of biomaterials, Modifications of Biomaterials, Role of Nanotechnology.

UNIT IV

BASIC BIOLOGY OF STEM CELLS

9

Stem Cells: Introduction, hematopoietic differentiation pathway Potency and plasticity of stem cells, sources, embryonic stem cells, hematopoietic and mesenchymal stem cells, Stem Cell markers, FACS analysis, Differentiation,Stem cell systems- Liver, neuronal stem cells, Types & sources of stem cell with characteristics: embryonic, adult, haematopoetic, fetal, cord blood, placenta, bone marrow, primordial germ cells, cancer stem cells induced pleuripotent stem cells.

UNIT V

CLINICAL APPLICATIONS

9

Stem cell therapy, Molecular therapy, In vitro organogenesis, Neurodegenrative diseases, spinal cord injury, heart disease, diabetes, burns and skin ulcers, muscular dystrophy, orthopedicapplications, Stem cells and Gene therapy Physiological models, issue engineered therapies, product characterization, components, safety, efficacy. Preservation –freezing and drying. Patent protection and regulation of of tissue-engineered products, ethical issues.

TOTAL :45 PERIODS

OUTCOMES: Upon completion of this course, the students would get
• Ability to understand the components of the tissue architecture
• Opportunity to get familiarized with the stem cell characteristics and their relevance in medicine
• Awareness about the properties and broad applications of biomaterials
• Overall exposure to the role of tissue engineering and stem cell therapy in Organogenesis

TEXT BOOKS:
1. Bernhard O.Palsson, Sangeeta N.Bhatia, ”Tissue Engineering” Pearson Publishers 2009.
2. Meyer, U.; Meyer, Th.; Handschel, J.; Wiesmann, H.P. .Fundamentals of Tissue Engineering and Regenerative Medicine.2009.

REFERENCES
1. Bernard N. Kennedy (editor). Stem cell transplantation, tissue engineering, and cancer applications, Nova Science Publishers, 2008.
2. Raphael Gorodetsky, Richard Schäfer..Stem cell-based tissue repair. RSC Publishing, 2011.
3. R. Lanza, I. Weissman, J. Thomson, and R. Pedersen, Handbook of Stem Cells, Two- Volume, Volume 1-2: Volume 1-Embryonic Stem Cells; Volume 2-Adult & Fetal Stem Cells, Academic Press, 2004.
4. R. Lanza, J. Gearhart etal (Eds), Essential of Stem Cell Biology, Elsevier Academic press,2006.
5. J. J. Mao, G. Vunjak-Novakovic et al (Eds), Translational Approaches In Tissue Engineering & Regenrative Medicine” Artech House, INC Publications, 2008.
6. Naggy N. Habib, M.Y. Levicar, , L. G. Jiao,.and N. Fisk, Stem Cell Repair and Regeneration, volume-2, Imperial College Press,2007.

Comments

Popular posts from this blog

CS3491 Syllabus - Artificial Intelligence And Machine Learning - 2021 Regulation Anna University

BE3251 - Basic Electrical and Electronics Engineering (Syllabus) 2021-regulation Anna University

CS3401 Syllabus - Algorithms - 2021 Regulation Anna University