BT8304 - BIOORGANIC CHEMISTRY (Syllabus) 2017-regulation Anna University

BT8304 - BIOORGANIC CHEMISTRY (Syllabus) 2017-regulation Anna University

BT8304	BIOORGANIC CHEMISTRY	LPTC

3003

OBJECTIVES: To enable the students

• To know in detail about the elements of atom, charges and their bonding rule. • To understand the various kinetic properties and types of reaction mechanisms • To understand the possible bio-organic reactions involved in biosynthesis

UNIT I	BONDING AND STEREOCHEMISTRY	9

Atoms Electrons and orbitals - Covalent Bonds - Octet rule - Polar covalant Bonds - Electronegativity- formal charge - Resonance Acids and Bases - Arrhenius and Bronsted Lowry Theories - Acid Base equilbria - SP3 hybridization - Conformations analysis ethane, butane and cyclohexane - Cis- trans isomerism. Stereochem activity around the tetrahedral carbon – optical activity - Conformation of the peptide bond.

UNIT II	MECHANISMS OF SUBSTITUTION AND ADDITION REACTIONS	9

SN1 and SN2 reactions on tetrahedral carbon- nucleophiles- mechanism steric effects – nucleophilic addition on Acetals and ketals -Aldehyde and ketone groups – reactions of carbonyl group with amines- acid catalyzed ester hydrolysis – Saponification of an ester- hydrolysis of amides. Ester enolates - claisen .condensation – Michael condensation.

UNIT III	KINETICS AND MECHANISM	9

Kinetic method – Rate law and mechanism – Transition states- Intermediates – Trapping of intermediates – Microscopic reversibility – Kinetic and thermodynamic reversibility – Isotopes for detecting intermediates. Primary and secondary isotopes – the Arrhenius equation Eyring equation - ΔG, ΔS, ΔH, Thermodynamics of coupled reactions.

UNIT IV	CATALYSIS	9

Reactivity – Coenzymes – Proton transfer – metal ions – Intra molecular reactions – Covalent catalysis – Catalysis by organized aggregates and phases. Inclusion complexation

UNIT V	BIOORGANIC REACTIONS	9

Timing of Bond formation and fission – Acyl group transfer – C-C bond formation and fission – Catalysis of proton transfer reactions – Transfer of hydride ion – Alkyl group. Transfer – Terpene biosynthesis – Merrifield state peptide synthesis – Sanger method for peptide and DNA sequencing

TOTAL : 45 PERIODS

OUTCOME:

• On completion of this course, the students will learn the basics principles of chemical Bonding, Stereochemistry of Bio-organic molecules and their kinetics, mechanisms of reactions and catalysis.

TEXT BOOKS:

1. Carey, Francis A.” Organic Chemistry”. VIIth Edition, Tata MCGraw Hill, 2009.
2. Page, M.I. and Andrew Williams “Organic and Bio-organic Mechanisms”. Pearson, 2010.

REFERENCE:

1. Dugas, Hermann “ Bioorganic Chemistry: A Chemical Approach to Enzyme Action” 3rd Edition, Springer, 2003.