BT8791 - IMMUNOLOGY (Syllabus) 2017-regulation Anna University

BT8791 - IMMUNOLOGY (Syllabus) 2017-regulation Anna University

BT8791

IMMUNOLOGY

 LPTC
3003

OBJECTIVES:
• To discuss the structure, functions and integration of immune system.
• To explain the antigen-antibody interactions and how the immune system is protecting the body from foreign pathogens/germs.
• To explain various techniques of monoclonal and engineered antibodies (important therapeutic molecules) production, for treating most of the human diseases.

UNIT I

INTRODUCTION TO IMMUNE SYSTEM

9
Organisation and classification of immune system – immune cells and organs; innate and acquired immunity; Toll receptors and responses, classification of antigens – chemical and molecular nature; haptens, adjuvants; cytokines; complement pathway, antigen presenting cells; major histocompatibility complex

UNIT II

HUMORAL AND CELLULAR IMMUNITY

9
Development, maturation, activation, regulation, differentiation and classification of T-cells and B- cells, antigen processing and presentation, theory of clonal selection, TCR; antibodies: structure and functions; antibodies: genes and generation of diversity; antigen-antibody reactions


UNIT III

IMMUNITY AGAINST PATHOGENS AND TUMORS

9
Inflammation; protective immune responses to virus, bacteria, fungi and parasites; tumor antigens, tumor immune response, tumor diagnosis, tumor immunotherapy

UNIT IV

IMMUNE TOLERANCE AND HYPERSENSITIVITY

9
Immune tolerance, Immuno deficiencies; Transplantation – genetics of transplantation; laws of transplantation; Allergy and hypersensitivity – Types of hypersensitivity, Autoimmunity, Auto immune disorders and diagnosis

UNIT V

APPLIED IMMUNOLOGY

9
Monoclonal antibodies, engineering of antibodies; Classification of Vaccines, methods of vaccine development, immunodiagnostic methods (Immuno diffusion ELISA, FACS), immune modulatory drugs

TOTAL : 45 PERIODS

OUTCOMES:
• The students after completing the course would be aware of immune system structure and functions.
• The students would be aware of immunity to various pathogens
• The students would be aware of the principles behind the production of therapeutic/ diagnostic molecules.
• The students would be aware of the concepts and mechanism behind tumour development, allergy and hypersensivity reactions.

TEXT BOOKS:
1. Peter J Delves, Seamus J Martin, Dennis R Burtn and Ivan M Roitt., Roitts Essential Immunology, 13th Edition, Wiley –Blackwell, 2016.
2. Judith a Owen, Jenni Punt and Sharon A Stranford, Kuby Immunology, Macmillan Internation, 7th Edition, 2012
3. Ashim K. Chakravarthy, Immunology, Tata McGraw-Hill, 2006.

REFERENCES:
1. Coico, Richard “Immunology: A Short Course” VIth Edition. John Wiley, 2008.
2. Khan, Fahim Halim “Elements of Immunology” Pearson Education, 2009.
3. Robert R Rich, Thomas A Fleisher, William T Shearer, Harry Schroeder, Anthony J Frew, and Cornelia M Weyand, Clinical Immunology – Principles and Practive, Elsevier, 4th Edition, 2013.
4. Maurice R, G O`Gorman, and Albert D Donnnenberg, Handbook of human Immunology, Second edition, CRC Press, 2008
5. Gerd – Rudiger Burmester, Antonio Pezzutto and Jurgen Wirth, Colour atlas of immunology, Thieme Medical ublishers, 1st edition, 2003.
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