PY6002 - UNIT PROCESS IN ORGANIC SYNTHESIS (Syllabus) 2013-regulation Anna University

PY6002 - UNIT PROCESS IN ORGANIC SYNTHESIS (Syllabus) 2013-regulation Anna University

PY6002	UNIT PROCESS IN ORGANIC SYNTHESIS	LPTC

3003

OBJECTIVE:

To provide the basic concepts and fundamental principles of various process in organic synthesis.

UNIT I	SULFONATION AND SULFATION	9

Sulfating – Sulfonating agents – Applications – Chemical and physical factors in sulfonation and sulfation – Thermodynamics mechanism – Kinetic considerations –Industrial equipments and techniques – Sulfonation of benzene – Aniline.

UNIT II	NITRATION	9

Nitrating agents – Aromatic nitration – Thermodynamics – Kinetics of nitration process – Nitration of benzene – Toluene – Phenol – Glycerine – Naphthalene – Industrial equipments for nitration – Preparation of m-dinitrobenzene – Chloro-nitro benzenes –Continuous nitration process

UNIT III	AMINATION BY REDUCTION	9

Methods of reduction – Bechamp method – Reduction mechanism – Preparation of aniline, p- phenylene diamine – Catalytic hydrogenation process – Catalyst involved in the reduction process – Reduction mechanism – Manufacture of aniline using catalytic reduction – Manufacture of p-aminophenol – Electrolytic reduction.

UNIT IV	HALOGENATION	9

Halogenating agents – Thermodynamic and kinetic considerations – Chlorination of methane – Ethane – Propane – Photohalogenation – Manufacture of allyl chloride –Chloroacetic acid – Chloral hydrate – Ethylene chlorohydrin – Chloromethane – Vinyl chloride.

UNIT V	OXIDATION	9

Oxidation reactions – Oxidizing agents – Liquid phase and vapour phase oxidation with air and oxygen – Catalysts used – Kinetics and thermodynamic considerations –Manufacture of phthalic anhydride – Acetaldehyde – Acetic acid – Benzaldehyde –Salicylic acid.

TOTAL : 45 PERIODS

OUTCOMES: The student will be able to

• Understand the nature of different chemical agents involved in sulfonation, nitration, reductive amination, halogenation and oxidation reaction.
• Understand and apply the principles of thermodynamics and kinetics in various commercially important chemical reactions.

TEXT BOOKS:

1. Groggins, P.H., “Unit Processes in Organic Synthesis”, 5th Edition, McGraw HillLtd., 1995.
2. Morison, R.T. and Boyd, R.N., “Organic Chemistry”, 6th Edition, Prentice Hall of India (P) Ltd, 2006.

REFERENCES:

1. Mukherjee, S. and Singh, S.P., “Reaction Mechanism in Organic Chemistry”, 3rd Edition, Mc Millan India Ltd., 2000.
2. Jerry, M., “Advanced Organic Chemistry – Reactions, Mechanism and Structure”, 4th Edition, John-Wiley and Sons, 1992.
3. Bruckner, R., “Advanced Organic Chemistry- Reactions Mechanisms”, Academic Press,