PY6013 - TECHNOLOGY OF FINE CHEMICALS AND BULK DRUGS (Syllabus) 2013-regulation Anna University

PY6013 - TECHNOLOGY OF FINE CHEMICALS AND BULK DRUGS (Syllabus) 2013-regulation Anna University

PY6013

TECHNOLOGY OF FINE CHEMICALS AND BULK DRUGS

 LPTC

3003

OBJECTIVE:
To enable the students about the plant design, Production technique and process Chemistry involved in the Fine chemicals and Bulk drug industry.

UNIT I

INTRODUCTION OF FINE CHEMICALS AND BULK DRUGS

9

Concept of fine and Bulk drugs and their salient features – Evolution o f process – Process chemistry – Research and development strategies in pharmaceutical industries.

UNIT II

PRODUCTION, PLANNING AND CONTROL

9

Flow sheets – Types of flow sheets – Flow symbols – Line symbols – Concept of all purpose and multipurpose plants – Plant design – Layout –– Process economics – Materials of construction – Effluent treatment – Solvent recovery for fine chemicals – Bulk drugs.


UNIT III

BASE CHEMICAL PRODUCTION

9

Industrial Production of following base chemicals – Mineral acids (sulpuric acid, nitric acid, phosphoric acid) – Naphthalene – Ammonia – Caustic soda – Industrial alcohol – Butyl alcohol – Benzene – Phenol.

UNIT IV

DRUG INTERMEDIATES AND FINE CHEMICAL PRODUCTION

9

Manufacture of following chemicals and their applications – Urea – Acrylonitrile – Ethylacetate – Butadiene – Quinoline – Aniline – Tetrahydrofuran – Titaniumdioxide – Vanillin.

UNIT V

BULK DRUGS

9

Raw Materials – Production Techniques – Reaction Flow Sheet – Equipments – Utilities for the production of drugs below – Paracetamol – Aspirin – Ibuprofen – Diazepam – Darvon – Niacinamide – Chloramphenicol, Erythromycin.

TOTAL : 45 PERIODS

OUTCOMES: The student will be able to
• Understand the principle of plant design in bulk drug industry.
• Understand the knowledge of base chemicals, drug intermediates and bulk drugs
• Understand kinetics, thermodynamics and plant construction material for the production of bulk drugs and fine chemicals.

TEXT BOOKS:
1. Gopal Rao, M. and Sittig, M., “Dryden’s Outlines of Chemical Technology”, 3rd Edition, Affiliated East West Press Pvt. Ltd., 2001.
2. Austin, G.T., “Shreve’s Chemical Process Industries”, 5th Edition, McGraw Hill Book Company, 1984.

REFERENCES:
1. Coulson and Richadson, “Chemical Engineering”Vol 6,3rd edition,Butterworth Heinemann, 2000.
2. Shah, K.M., “Hand Book of Industrial Chemistry”, Vol. I and II, Multi-Tech Publishing Co, 1999.
3. Pandey, G.N., “A Text Book of Chemical Technology”, Vol. II, Vikas Publishing House (P) Ltd., 2000.

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