PY6301 - PHARMACEUTICAL CHEMISTRY (Syllabus) 2013-regulation Anna University
PY6301 - PHARMACEUTICAL CHEMISTRY (Syllabus) 2013-regulation Anna University
PY6301 |
PHARMACEUTICAL CHEMISTRY |
LPTC |
---|
3003
OBJECTIVES:
• To inculcate understanding of the properties and principles of medicinal agents that originates from organic and inorganic sources and their application in pharmaceutical industry
• To provide the basic functional group identification, chemical bonding with their mechanism.
• To provide the basic principles involved in the identification and estimation of pharmaceutical substances.
• To provide the basic functional group identification, chemical bonding with their mechanism.
• To provide the basic principles involved in the identification and estimation of pharmaceutical substances.
UNIT I |
STRUCTURE AND PROPERTIES |
9 |
---|
Molecular orbital theory, hybrid orbitals, polarity of bonds and molecules, dipole moment, resonance, inductive, mesomeric and electromeric effects, intramolecular and intermolecular hydrogen bonding.
UNIT II |
CHEMISTRY OF ALIPHATIC AND AROMATIC COMPOUNDS |
10 |
---|
Characteristics of organic compounds, structure, nomenclature, preparation and reaction mechanism of alkyl and aryl halides (Mechanism of SN1, SN2, E1 and E2), Huckel rule, structures of benzenoid and nonbenzenoid compounds, mechanism of aromatic electrophilic and nucleophilic substitution, general mechanism of an aromatic electrophilic substitution reaction. alcohols, ethers, epoxides, amines, aldehydes, ketones, carboxylic acids and functional derivatives of carboxylic acids.
UNIT III |
PRINCIPLES OF TEST FOR PURITY IN PHARMACEUTICAL SUBSTANCES |
9 |
---|
Identification and characterization of impurities in Pharmaceutical substances, Limit tests: Definition, importance, general procedure for limit test for chlorides, sulphates, iron, arsenic, heavy metals, lead and modifications with suitable examples.
UNIT IV |
STUDY OF INORGANIC COMPOUNDS IN PHARMACOPOEIA |
12 |
---|
Method of preparation, assay, identification test, test for purity, official preparation, storage conditions and belonging to the following categories. Gastrointestinal agents and related compounds – Acidifiers, Antacids, Adsorbents and protectives, Saline cathartics; Topical Agents – Protectives, Astringents, Anti-microbials topical agents.
UNIT V |
PHARMACEUTICAL AIDS AND CO-ORDINATION COMPOUNDS |
10 |
---|
Definition, principles and properties of various agents such as – Sodium bisulphate, Sodium metabisulphate, Sulphurdioxide, Bentonite, Magnesium stearate, Zinc stearate, Aluminium sulphate, Sodium carboxy methyl cellulose, Sodium methylparaben Theory of co-ordination compounds with special reference to application in Pharmacy such as – EDTA, Dimercaprol, Penicillamine, 1, 10-Phenanthroline
TOTAL : 45 PERIODS
OUTCOMES: The student will be able to
• Identify the functional groups in pharmaceutical substances and make predictions of chemical bonding along with their reaction mechanism.
• Identify and estimate the purity of drugs and its application.
• Involve in the development and synthesis of new drug molecule.
• Identify and estimate the purity of drugs and its application.
• Involve in the development and synthesis of new drug molecule.
TEXT BOOKS:
1. AB.S. Bahl and Arun Bahl.ATextbook of Organic Chemistry 21 Edition, S.Chand and company pvt.Ltd, New Delhi.
2. Atherden, L.M. “Bentley and Driver’s Textbook of Pharmaceutical Chemistry”. Oxford University Press, 8th Edition, 1977.
2. Atherden, L.M. “Bentley and Driver’s Textbook of Pharmaceutical Chemistry”. Oxford University Press, 8th Edition, 1977.
REFERENCES:
1. Indian Pharmacopoeia (I.P.) 2007
2. A.I. Vogel, B.S. Furniss, A.J. Hannaford, P.W.G. Smith, and A.R. Tatchell, Vogels textbooks of practical organic chemistry,. 5th Ed., ELBS longman, 1994.
3. Morrison R.T., Boyd R.N., Organic Chemistry,Prentice- Hall of India, 6th ed., (1992)
2. A.I. Vogel, B.S. Furniss, A.J. Hannaford, P.W.G. Smith, and A.R. Tatchell, Vogels textbooks of practical organic chemistry,. 5th Ed., ELBS longman, 1994.
3. Morrison R.T., Boyd R.N., Organic Chemistry,Prentice- Hall of India, 6th ed., (1992)
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