PY6404 - PHYSICAL PHARMACEUTICS (Syllabus) 2013-regulation Anna University

PY6404 - PHYSICAL PHARMACEUTICS (Syllabus) 2013-regulation Anna University

PY6404

PHYSICAL PHARMACEUTICS

 LPTC

3003

OBJECTIVES:
• To provide the fundamentals such as power characters and rheology.
• To provide the knowledge about the stability.

UNIT I

MICROMERITICS AND POWDER RHEOLOGY

10

Particle size and distribution, average particle size, number and weight distribution, particle number, methods for determining particle volume, optical microscopy, sieving, sedimentation, measurement of particle shape, specific surface, methods for determining surface area, permeability, adsorption, derived properties of powders, porosity, packing arrangement, densities, bulkiness and flow properties.

UNIT II

SURFACE, INTERFACIAL PHENOMENON, VISCOSITY AND RHEOLOGY

10

Liquid interface, surface and interfacial tension, surface free energy, measurement of surface and interfacial tensions, free energy, spreading coefficient, adsorption at liquid interfaces, surface active agents, HLB classification, solubilization, detergency, adsorption at solid interface, solid gas and solid-liquid interface, complex films, electrical properties of interface. Newtonian system, Law of flow, kinematic viscosity, effect of temperature, non-Newtonian systems, pseudoplastic, dilatant, plastic, thixotropy, thixotropy in formulation, determination of viscosity: capillary, falling ball, rotational viscometers.


UNIT III

DISPERSION SYSTEMS

10

Colloidal dispersions: Definition, types, properties of colloids, protective colloids, applications of colloids in pharmacy. Suspensions and Emulsions : Interfacial properties of suspended particles, settling in suspensions, theory of sedimentation, effect of Brownian movement, sedimentation of flocculated particles, sedimentation parameters, wetting of particles, controlled flocculation, flocculation in structured vehicle, rheological considerations, emulsions ; types, theories, physical stability.

UNIT IV

DIFFUSION & DISSOLUTION

5

Definitions, Steady state diffusion, Procedures and apparatus, Dissolution, Drug release. Complexation and protein binding Metal complexes, organic molecular complexes, inclusion compounds, methods of analysis, protein binding, complexation and drug action, crystalline structures of complexes and thermodynamic treatment of stability constants.

UNIT V

KINETICS AND DRUG STABILITY

10

General considerations and concepts, half-life determination, Influence of temperature, light, catalytic species, solvent and other factors, Accelerated stability study, expiration dating.

TOTAL : 45 PERIODS

OUTCOMES: The student will be able to
• Deal the manufacturing problems in pharmaceutical formulations.
• Acquire the knowledge of drug stability and expiry date determination

TEXT BOOKS:
1. Sinko, Patrick J. “Martin’s Physical Pharmacy and Pharmaceutical Sciences“5th edition, Wolters, Kluwer/ Lippincott Williams & Wilkins Publishing, 2006
2. Manavalan, R. and C. Ramasamy. “Physical Pharmaceutics” Vignesh Publishers, 2nd Ed., 2011.

REFERENCES:
1. Martin’s Physical Pharmacy and Pharmaceutical Sciences, Fifth edition, Patrick J. Sinko (ED), Lippincott Williams & Wilkins 2006.
2. Laura Moore Fox, Remington: The science and practice of pharmacy, 21st Edition, Lippincott Williams and Wilkins, 2005
3. Monihan, Humphery and Abina Gean “The Physicochemical Basis of Pharmaceuticals” Oxford University Press, 2009.

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