PY6502 - ANALYTICAL METHODS OF PHARMACEUTICALS (Syllabus) 2013-regulation Anna University

PY6502 - ANALYTICAL METHODS OF PHARMACEUTICALS (Syllabus) 2013-regulation Anna University

PY6502

ANALYTICAL METHODS OF PHARMACEUTICALS

 LPTC

3003

OBJECTIVES:
• To provide the concept of pharmacopoeia monograph.
• To provide the fundamental and principles of various analytical instruments and its technique used in pharmaceutical industry.

UNIT I

PHYSICAL METHODS

9

Pharmaceutical Analysis - Qualitative and quantitative analysis – Significance- Pharmacopoeia, Physical methods: Melting point- boiling point - refractive index - optical rotation-density- specific gravity-gravimetry-thermogravimetry - uses, limitations, advantages, and method of determination for each method.

UNIT II

TITRATIONS

9

Acid base theory- Arrhenius, Bronsted-Lowry, Lewis acid- acid- base indicators, theory of, effective range and choice of, titration curves for acid-base titration, mixed solvents, non- aqueous titration, pharmacopoeial applications . Precipitation titration, Argentimetric titrations, Mohr’s method, Vollhard’s method, examples in pharmacopoeia, complexometric tritration, redox titrations, half reactions and half equations, redox equivalent weights, reduction potential, significance of reduction potential, standard reduction potentials, iodimetry, iodometry, iodine displacement reactions.


UNIT III

ULTRAVIOLET SPECTROSCOPY

9

Theory of atomic and molecular spectra, Electronic transitions, Beer and Lambert’s law, Derivation and deviations, Chromophores, Auxochromes, Spectral shifts, Solvent effect on absorption spectra.Instrumentation - Sources of radiation, wavelength selectors, sample cells, Detectors- Barrier layer cell, Photo tube, Photomultiplier tube, photodiode.Applications.

UNIT IV

INFRARED AND NMR SPECTROSCOPY

9

Principles of vibrational spectroscopy – Instrumentation and sampling technique – Applications in pharmaceutical sciences – NMR principles – Instrumentation – Applications.

UNIT V

CHROMATOGRAPHY

9

Thin Layer Chromatography Adsorbents, solvents, elutropic series, uses, limit test for impurities using TLC- known impurity, unknown impurity, HPLC High Performance Liquid Chromatography, technique, advantages, basic HPLC, Columns, Detectors, Qualitative analysis and Quantitative Analysis, Packing materials, Solvents, retention factor, symmetry factor, resolution, theoretical plate.

TOTAL : 45 PERIODS

OUTCOMES: The student will be able to
• Understand the various techniques in the field of Pharmaceutical Analysis.
• Choose proper analytical method for qualitative and quantification of the pharmaceutical substances.

TEXT BOOKS:
1. Atherden, L.M. “Bentley and Driver’s Textbook of Pharmaceutical Chemistry”. Oxford University Press, 8th Edition, 1977.
2. Siddiqui, Anees A. “Pharmaceutical Analysis”. Vol.I & II, CBS, 2006.

REFERENCES:
1. Kenneth A. Connors, “Text book of Pharmaceutical Analysis”, 3rd Edition, John wiley and sons, Newyork.1982.
2. Ohannesian, Lena and Streeter, A.J. “Handbook of Pharmaceutical Analysis”. Marcel Dekker, 2002.
3. Stahl, Egon “Thin – Layer Chromatography: A Laboratory Handbook”. Springer, 2nd Edition, 2005.

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