PY6504 - MEDICINAL CHEMISTRY (Syllabus) 2013-regulation Anna University

PY6504 - MEDICINAL CHEMISTRY (Syllabus) 2013-regulation Anna University

PY6504

MEDICINAL CHEMISTRY

 LPTC
3104

OBJECTIVE:
To provide the basic knowledge such as physicochemical properties, classification, structure activity relationship and mechanism of action of various medicinal agents.

UNIT I

PRINCIPLES OF MEDICINAL CHEMISTRY

9
Physicochemical properties in relation to biological action – Ionization, Drug distribution and pKa values, hydrogen bonding, protein binding, chelation, optical and geometrical isomerism, steric effect, redox potential and surface activity. Prodrugs –concepts/application of prodrug design.

UNIT II

MEDICINAL CHEMISTRY OF DRUGS ACTING ON ANS AND CNS

9
Classification, biochemical/molecular basis of mechanism of action, structure activity relationship including stereo chemical aspects, physiochemical properties and synthesis of selected drugs belonging to the class of sympathomimetic agents. adrenergic antagonists, Antipsychotics, Anticonvulsants, Analgesics.


UNIT III

MEDICINAL CHEMISTRY OF ANTI-INFECTIVE AGENTS

9
Structural basis of mechanism of action, structure activity relationship including stereo chemical aspects, physiochemical properties, and synthesis of selected drugs belonging to the class of sulphonamides, penicillins and cephalosporins, aminoglycosides and tetracyclines.

UNIT IV

MEDICINAL CHEMISTRY OF DRUGS ACTING ON CVS

9
Structural basis of mechanism of action, structure activity relationship including stereo chemical aspects, physiochemical properties, and synthesis of selected drugs belonging to the class of anti-anginal, vasodilators, calcium channel blockers and cardiac glycosides.

UNIT V

MEDICINAL CHEMISTRY OF ANTIHISTAMINIC AGENTS AND EICOSANOIDS

9
Classification, structure basis of mechanism of action, structure activity relationship including drugs acting on Histamine receptors, eicosanoids biosynthesis, drug action mediated by eicosanoids, design of eicosanoid drugs, antipyretics, anti-rheumatoid drugs and non- steroidal anti-inflammatory drugs.

TOTAL (L:45 + T:15) : 60 PERIODS

OUTCOMES: The student will be able to
• Understand the molecular basis, biochemical, physiochemical properties and synthesis of medicinal agents.
• Understand the mechanism of action, structure activity relationship including stereo chemical aspects of the medicinal agents acting on various physiological systems.

TEXT BOOKS:
1. Ashutosh Kar, Medicinal Chemistry, New Age International (P) Ltd., Publishers, New Delhi, 2005.
2. GrahamL.Patrick An introduction to Medicinal Chemistry 5th edition , Oxford University Press.2013.

REFERENCES:
1. Berger, A. Burger’s medicinal chemistry and Drug Discovery, Vol I to IV. 5thedition John Wiley and Sons,. (1991)
2. Foye W O, ed. Principles of Medicinal Chemistry, 2nd Ed. Philadelphia: Lea & Febiger, 1981.
3. Indian Pharmacopoeia, Vol 1&2, Indian Pharmacopoeia Commission 2010.
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