PY6601 - PHARMACEUTICAL DOSAGE FORMS (Syllabus) 2013-regulation Anna University

Title

PY6601

PHARMACEUTICAL DOSAGE FORMS

 LPTC

3104

OBJECTIVE:
To provide the concepts of various parameters involved in the formulation and development of various dosage forms.

UNIT I

PREFORMULATION STUDIES AND MONOPHASIC LIQUID DOSAGE FORMS

9

Physical/physicochemical properties of drugs - physical form, particle size, shape, density, wetting, dielectric constant, solubility, polymorphism, dissolution, organoleptic properties and their effect on formulation, stability and bioavailabilty. Dissolution process – Solubility and Physical characters of liquid dosage forms – Liquid formulations for internal use – external use.

UNIT II

BIPHASIC SYSTEMS AND SEMI SOLID DOSAGE FORMS

9

Emulsions – formulation of emulsions – stability – evaluation of emulsions – Suspensions – Formulations – problems in suspension – evaluation of suspensions – Suppositoreis – Suppository bases – formulation and packaging – formulation problems – processing of suppositories – drug availabilities from suppositories – evaluation of suppositories – Ointments – skin structure and drug absorption – ointment bases – additives – special type of ointments – processing and evaluation of ointments. Creams- formulation and evaluation


UNIT III

SOLID DOSAGE FORMS

9

Types of tablets - Tabletting equipments – Granulation technology – Formulation of Tablets – Processing problem of tablets and evaluation of tablets. Tablets Coating – Principles – Tablet coating process – Sugar coating – Film Coating – Specialized coating – Evaluation of coated tablets. Hard gelatin Capsules – Raw materials – Manufacture – Formulations – Filling equipments – Evaluations – Soft gelatin capsule – Rationale – Manufacture – Formulation – Evaluation.

UNIT IV

PARENTERAL PRODUCTS

9

Diversities of parenteral products – Formulation of parenteral products – Sustained action parenteral products – Processing and Packaging– Evaluation of parenteral products – specialized parentral products.

UNIT V

PHARMACEUTICAL AEROSOLS

9

Components of aerosol package – Formulation, Stability testing, Manufacture, Quality control and Testing of pharmaceutical aerosols

TOTAL (L:45 + T:15) : 60 PERIODS

OUTCOMES: The student will be able to
• Understand the factors influencing the development of various dosage forms.
• Understand the formulation concepts and evaluate different dosage forms to meet out the compendial requirements.

TEXT BOOKS:
1. Lachman, Leon et al. “The Theory and Practice of Industrial Pharmacy” 3rd Ed., Varghese Publishing House, 1987.
2. Aulton, Michael E. “Pharmaceutics: The Science of Dosage Form Design” 2nd Ed., Churchill Livingstone, 2002.
3. Allen, Loyd V. et al. “Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems” 9th Ed., Wolters Kluver/Lippin Cott Williams & Wilkins, 2011.

REFERENCES:
1. Avis, K.E. et al. “Pharmaceutical Dosage Forms: Parenteral Medications” Vol.1-3, 2nd Ed., Marcel Dekker, 2005.
2. Libermann, H.A. et al. “ Pharmaceutical Dosage Forms : Tablets” Vol.1-3, 2nd Ed., Marcel Dekker, 2005.
3. Libermann, H.A. et al., “Pharmaceutical dosage forms: Disperse Systems” Vol. 1-3, 2nd Ed., Marcel dekker, 2005.

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