PY8009 - TECHNOLOGY OF FINE CHEMICALS AND BULK DRUGS (Syllabus) 2017-regulation Anna University

PY8009 - TECHNOLOGY OF FINE CHEMICALS AND BULK DRUGS (Syllabus) 2017-regulation Anna University

PY8009

TECHNOLOGY OF FINE CHEMICALS AND BULK DRUGS

 LPTC

3003

OBJECTIVES:
• To study about the plant design, production techniques and process chemistry involved in the fine chemicals and bulk drug industry.

UNIT I

INTRODUCTION OF FINE CHEMICALS AND BULK DRUGS

9

Concept of fine and Bulk drugs and their salient features – Evolution of process – Process chemistry – Research and development strategies in pharmaceutical industries, Chemical process life cycle, Legislative requirements for safe process development and scale up.

UNIT II

PRODUCTION, PLANNING AND CONTROL

9

Flow sheets – Types of flow sheets – Flow symbols – Line symbols – Concept of all purpose and multipurpose plants – Plant design – Layout –– Process economics – Materials of construction – Effluent treatment and solvent recovery for fine chemicals and bulk drugs.


UNIT III

PROCESS DEVELOPMENT AND HAZARDS

9

Developing the best synthetic route; Selection of the best route for scale-up, Choice of raw materials and reagents, Development techniques for safe process design, Unit operations posing particular hazards during development, Strategies for chemical hazards assessment, Hazards of gas and vapor generation, Identification of highly-energetic materials.

UNIT IV

BASE CHEMICALS, DRUG INTERMEDIATES AND FINE CHEMICAL PRODUCTION

9

Manufacture of following chemicals and their applications – Sulphuric acid – Caustic soda – Ammonia – Phenol – Industrial alcohol - Urea – Acrylonitrile –Ethyl acetate – Butadiene – Aniline – Titanium dioxide –Vanillin.

UNIT V

BULK DRUGS PRODUCTION

9

Raw Materials – Production Techniques – Reaction Flow Sheet – Equipments – Utilities for the production of drugs below – Paracetamol – Aspirin – Ibuprofen – Diazepam – Vitamin C – Salbutamol – Ranitidine – Sulphamethoxazole – Cephalosporins – Erythromycin-Prednisolone.

TOTAL : 45 PERIODS

OUTCOMES: The student will be able to
• Apply the knowledge of the production techniques of fine chemicals and bulk drugs.
• Acquire the knowledge on plant design, process development and chemical hazards in fine chemical and bulk drug industry.
• Understand kinetics, thermodynamics and plant construction materials for the production of bulk drugs and fine chemicals.

TEXT BOOKS:
1. Gopal Rao, M. and Sittig, M., “Dryden’s Outlines of Chemical Technology”, 3rd Edition, Affiliated East West Press Pvt. Ltd., 2001.
2. Austin, G.T., “Shreve’s Chemical Process Industries”, 5th Edition, McGraw Hill BookCompany, 2012.
3. Pandey, G.N., “A Text Book of Chemical Technology”, Vol. II, Vikas Publishing House (P) Ltd., 2000.

REFERENCES:
1. Coulson and Richardson, “Chemical Engineering” Vol 6, 4th edition, Butterworth Heinemann, 2005.
2. Shah, K.M., “Hand Book of Industrial Chemistry”, Vol. I and II, Multi-Tech Publishing Co, 1999.
3. Neal G. Anderson, “Practical Process Research and Development” 1st Edition, academic Press, 2000

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