PY8014 - INTRODUCTION TO BIOMATERIALS AND TISSUE ENGINEERING (Syllabus) 2017-regulation Anna University

PY8014 - INTRODUCTION TO BIOMATERIALS AND TISSUE ENGINEERING (Syllabus) 2017-regulation Anna University

PY8014

INTRODUCTION TO BIOMATERIALS AND TISSUE ENGINEERING

 LPTC

3003

OBJECTIVE:
• The objective of this course is to enable the students to learn the fundamentals of tissue engineering and tissue repairing and to acquire knowledge on biomaterials and its applications

UNIT I

INTRODUCTION

10

Introduction to tissue engineering: Basic definition-current scope - cell numbers and growth rates- measurement of cell characteristics –morphology- number viability- motility and functions. Measurement of tissue characteristics - appearance- cellular component-ECM component- physical properties.

UNIT II

TISSUE ARCHITECTURE

8

Tissue types and Tissue components, Tissue repair and Engineering -wound healing and sequence of events - Cell-Matrix- Cell-Cell Interactions - telomeres and Self renewal- Control of cell migration in tissue engineering.


UNIT III

BIOMATERIALS

9

Biomaterials: Properties of biomaterials-Surface, bulk, mechanical and biological- Scaffolds & tissue engineering - Types of biomaterials-biological and synthetic materials- Biopolymers- Applications – Modifications - Role of Nanotechnology.

UNIT IV

BASIC BIOLOGY OF STEM CELLS

9

Stem Cells: Introduction- hematopoietic differentiation pathway -Potency and plasticity of stem cells- Stem Cell markers- Types and sources of stem cell with characteristics: embryonic- adult- haematopoietic- fetal- cord blood-placenta- bone marrow-primordial germ cells- cancer stem cells- induced pleuripotent stem cells.

UNIT V

CLINICAL APPLICATIONS

9

Stem cell therapy-Molecular therapy - In vitro Organogenesis-Neuro degenerative diseases- spinal cord injury- heart disease- diabetes- burns and skin ulcers- muscular dystrophy-orthopaedic applications - Patent protection and regulation of tissue engineered products- ethical issues.

TOTAL : 45 PERIODS

OUTCOMES: Upon completion of this course, the students would get
• Ability to understand the components of the tissue architecture
• Opportunity to get familiarized with the stem cell characteristics and their relevance in medicine
• Awareness about the properties and broad applications of biomaterials
• Overall exposure to the role of tissue engineering and stem cell therapy in organogenesis

TEXT BOOKS:
1. Bernhard O.Palsson, Sangeeta N.Bhatia, ”Tissue Engineering” Pearson Publishers 2009.
2. Meyer, U.; Meyer, Th.; Handschel, J.; Wiesmann, H.P. Fundamentals of Tissue Engineering and Regenerative Medicine. 2009.
3. R. Lanza, J. Gearhart et al (Eds), Essential of Stem Cell Biology, Elsevier Academic press, 2006.

REFERENCES:
1. J.J. Mao, G.Vunjak-Novakovic et al (Eds), Translational Approaches in Tissue Engineering & Regenerative Medicine” Artech House, INC Publications, 2008
2. Bernard N. Kennedy (editor), Stem cell transplantation, tissue engineering, and cancer applications, New York: Nova Science Publishers, 2008.
3. Raphael Gorodetsky, Richard Schäfer Stem cell- based tissue repair, Cambridge: RSC publishing, 2011.

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