PY8301 - PHARMACEUTICAL CHEMISTRY (Syllabus) 2017-regulation Anna University

PY8301 - PHARMACEUTICAL CHEMISTRY (Syllabus) 2017-regulation Anna University

PY8301	PHARMACEUTICAL CHEMISTRY	LPTC

3003

OBJECTIVES:

• To inculcate understanding of the properties and principles of medicinal agents that originates from organic and inorganic sources and their application in pharmaceutical industry.
• To provide the basic functional group identification, molecular rearrangement, chemical bonding with their reaction mechanism.
• To provide the fundamental principles involved in the identification, preparation of pharmaceutical aids and to apply the principle of coordination compounds in pharmaceutical substances.

UNIT I	STRUCTURE AND PROPERTIES	9

Molecular orbital theory, hybrid orbitals, polarity of bonds and molecules, dipole moment, resonance, inductive, mesomeric and electromeric effects, intramolecular and intermolecular hydrogen bonding.

UNIT II	CHEMISTRY OF ALIPHATIC, AROMATIC AND HETEROAROMATIC COMPOUNDS	9

Characteristics of organic compounds, structure, nomenclature, preparation and reaction mechanism of alkyl and aryl halides (Mechanism of SN1, SN2, E1 and E2), Huckel’s rule, structures, synthesis, properties and chemical reactions of benzenoid and nonbenzenoid compounds, mechanism of aromatic electrophilic and nucleophilic substitution. General principles of heterocyclic synthesis – Methods of preparation and reactions of Pyridines – Pyrroles – Thiophenes – Furans – Quinolines – Isoquinolines.

UNIT III	PRINCIPLES OF TEST FOR PURITY IN PHARMACEUTICAL SUBSTANCES	9

Identification and characterization of impurities in Pharmaceutical substances, Limit tests: Definition, importance, general procedure for limit test for chlorides, sulphates, iron, arsenic, heavy metals and lead with suitable examples.

UNIT IV	STUDY OF ORGANIC REACTIONS AND MOLECULAR REARRANGEMENTS	9

Hoesch reaction, Formylation reactions, Gattermann Reaction, Gattermann-Koch reaction, Vilsmeier reaction, Reimar-Tiemann reaction, Wolff rearrangement, Schmidt reaction. Curtius rearrangement, Catalytic dehydrogenation, Meerwein-Ponndorf-Verley, NaBH4, Clemmenson, Sandmeyer, Ullmann, Azo coupling, Deamination, Benzidine rearrangement.

UNIT V	PHARMACEUTICAL AIDS AND CO-ORDINATION COMPOUNDS	9

Preparation and properties of various agents such as – Sodium bisulphate, Sodium metabisulphate, Sulphur dioxide, Bentonite, Magnesium stearate, Zinc stearate, Aluminium sulphate, Sodium carboxy methyl cellulose, Sodium methylparaben- Theory of co-ordination compounds with special reference to application in Pharmacy such as – EDTA, Dimercaprol, Penicillamine, 1, 10-Phenanthroline.

TOTAL : 45 PERIODS

OUTCOMES: The student will be able to

• Identify the functional groups in pharmaceutical substances and make predictions of chemical bonding along with their reaction mechanism.
• Identify and estimate the purity of drugs and its application.
• Apply the knowledge in the development and synthesis of new drug molecule with special reference to organic, inorganic and coordination chemistry.

TEXT BOOKS:

1. Francis A. Carey (Author), Richard J. Sundberg, Advanced Organic Chemistry, Part A: Structure and Mechanisms 5th Edition, Springer Publishers, 2000.
2. N V Chenchu Lakshmi, Pharmaceutical Inorganic chemistry: Theory and practice, 1stEdition,Pearson Education India,2012.
3. R.K. Sharma, Text Book of Coordination Chemistry, 1stEdition,Discovery Publishing House Pvt. Ltd.2011.

REFERENCES:

1. Michael B. Smith, Jerry March, March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, 6thEdition,Wiley,2007
2. Lutz F. Tietze, Theophil Eicher, Ulf Diederichsen, Andreas Speicher, Reactions and Syntheses in the Organic Chemistry Laboratory, 1st Edition, Wiley – VCH,2007
3. P. L. Soni, VandnaSoni, Coordination Chemistry: Metal Complexes, 1st Edition, CRC Press, 2013.