PY8302 - PHYSICAL PHARMACEUTICS (Syllabus) 2017-regulation Anna University

PY8302 - PHYSICAL PHARMACEUTICS (Syllabus) 2017-regulation Anna University

PY8302

PHYSICAL PHARMACEUTICS

 LPTC

3003

OBJECTIVES:
• To acquire the fundamental principles and concepts involved in pharmaceutical powders, liquid flow, dispersions, drug diffusion, dissolution, complexation and protein binding.
• To provide the knowledge about kinetics and drug stability

UNIT I

MICROMERITICS AND POWDER RHEOLOGY

9

Particle size and distribution, particle number, methods for determining particle volume, optical microscopy, sieving, sedimentation, Dynamic light scattering (DLS) technique, measurement of particle shape, specific surface, methods for determining surface area, permeability, adsorption, derived properties of powders, porosity, packing arrangement, densities, bulkiness and flow properties.

UNIT II

SURFACE AND INTERFACIAL PHENOMENON, VISCOSITY AND RHEOLOGY

9

Liquid interface, surface and interfacial tension, surface free energy, measurement of surface and interfacial tensions, free energy, spreading coefficient, adsorption at liquid interfaces, surface active agents, HLB classification, solubilization, detergency, adsorption at solid interface, solid gas and solid-liquid interface, complex films, electrical properties of interface. Newtonian system, Law of flow, kinematic viscosity, effect of temperature on viscosity, non-Newtonian systems, plastic, pseudoplastic, dilatant, thixotropy, thixotropy in formulation, determination of viscosity: capillary, falling ball, rotational viscometers.


UNIT III

DISPERSION SYSTEMS

9

Colloidal dispersions: Definition, types, properties of colloids, protective colloids, applications of colloids in pharmacy. Suspensions and Emulsions: Interfacial properties of suspended particles, settling in suspension, theory of sedimentation, effect of Brownian movement, sedimentation of flocculated particles, sedimentation parameters, wetting of particles, controlled flocculation, flocculation in structured vehicle, rheological considerations, emulsions; types, theories, physical stability.

UNIT IV

DIFFUSION, DISSOLUTION, COMPLEXATION &PROTEIN BINDING

9

Definitions, Steady state diffusion, Procedures and apparatus for diffusion, dissolution and drug release, factors affecting dissolution, Complexation and protein binding; Metal complexes, organic molecular complexes, inclusion compounds, methods of analysis of complexes, crystalline structures of complexes and thermodynamic basis of stability constants. Protein binding and drug action, protein binding studies.

UNIT V

KINETICS AND DRUG STABILITY

9

General considerations and concepts of drug reaction kinetics; zero order, first order and pseudo first order, half-life determination, Influence of temperature, light, catalytic species, solvent and other factors, Stabilization of drugs, Accelerated stability study, expiration dating.

TOTAL : 45 PERIODS

OUTCOMES:
• To know the fundamental properties of pharmaceutical solids
• To understand the surface, interfacial phenomena and the rheology of liquids
• Ability to understand the principles, characters and applications of pharmaceutical dispersions.
• To acquire the knowledge about drug diffusion, dissolution, complexation and protein binding.
• To be familiar with the degradation pathways, stabilization of drugs and their expiry date calculation.

TEXT BOOKS:
1. Manavalan, R. and Ramasamy. C. “Physical Pharmaceutics” 2nd Ed., Vignesh Publishers, 2015.
2. C.V.S. Subrahmanyam, Text book of physical pharmaceutics, 3rdEdn., Vallabhprakashan, 2015.
3. Hadkar. U. B., Physical Pharmacy, NiraliPrakashan; 12th edition, 2017.

REFERENCES:
1. Alfred N. Martin, Patrick J. Sinko, Martin’s Physical Pharmacy and Pharmaceutical Sciences: Physical Chemical and Biopharmaceutical Principles in the Pharmaceutical Sciences, sixth edition, Lippincott Williams & Wilkins, 2011.
2. David B. Troy, Paul Beringer, Remington: The science and practice of pharmacy, 21st Edition, Lippincott Williams and Wilkins, 2006
3. Humphrey Moynihan and Abinacrean “Physicochemical Basis of Pharmaceuticals” Oxford University Press, 2009.

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