PY8405 - PHARMACEUTICAL ANALYSIS (Syllabus) 2017-regulation Anna University
PY8405 - PHARMACEUTICAL ANALYSIS (Syllabus) 2017-regulation Anna University
PY8405 |
PHARMACEUTICAL ANALYSIS |
LPTC |
---|
3003
OBJECTIVE:
• To facilitate students to acquire knowledge about the principles and operations of various modern analytical instruments.
UNIT I |
UV-VISIBLE SPECTROSCOPY |
9 |
---|
Theory of atomic and molecular spectra, Electronic transitions, Beer and Lambert’s law, Derivation and deviations, Chromophores, Auxochromes, Spectral shifts, Solvent effect on absorption spectra. Instrumentation - Sources of radiation, wavelength selectors, sample cells, Detectors- Barrier layer cell, Photo tube, PMT, PDA detectors; Applications in pharmaceuticals.
UNIT II |
ATOMIC ABSORPTION SPECTROSCOPY |
9 |
---|
Principles, Instrumentation, Operation – single and double beam spectroscopy; sampling technique – Detection limit, Difference between Atomic absorption spectroscopy and Flame spectroscopy; Applications in pharmaceuticals.
UNIT III |
INFRARED AND NMR SPECTROSCOPY |
9 |
---|
Principles of vibrational spectroscopy – Instrumentation and sampling techniques – Applications in pharmaceutical sciences – NMR principles – Instrumentation – Applications in pharmaceuticals.
UNIT IV |
MASS SPECTROMETRY |
9 |
---|
Basic principles, instrumentation and ionization methods; atmospheric pressure ionization (API), chemical ionization (CI), electron impact ionization (EI), fast atom bombardment (FAB), matrix assisted laser desorption ionization (MALDI), time of flight (TOF); Applications in pharmaceuticals.
UNIT V |
CHROMATOGRAPHIC METHODSc |
9 |
---|
History, origin and classification of chromatography: Column Chromatography: principle, theory, column operations, instrumentation, derivatisation methods and applications; High Performance Liquid Chromatography: Principle, instrumentation, solvents system, packing materials and applications; Thin Layer Chromatography: Principle, instrumentation, solvents, packing materials and applications in pharmaceuticals.
TOTAL : 45 PERIODS
OUTCOMES:
• Develops ability to handle the modern analytical instruments like UV/Vis, IR, NMR, Mass spectroscopy and HPLC.
• Develops ability to involve in Qualitative and Quantitative analysis of various pharmaceutical agents.
• Develops ability to involve in phytochemical and biological standardization of pharmaceutical products.
• Develops ability to involve in Qualitative and Quantitative analysis of various pharmaceutical agents.
• Develops ability to involve in phytochemical and biological standardization of pharmaceutical products.
TEXT BOOKS:
1. A. H. Beckett & J. B. Stenlake, “Practical Pharmaceutical Chemistry”, Part II, 4th Edition,Bloomsbury Academic, 2001.
2. Hobert H. Willard, “Instrumental Methods of Analysis”, 7th Edition,CBS Publishers & Distributors, 2004.
3. B.K. Sharma, “Instrumental Method of Chemical Analysis”, Krishna’s Education Publishers, 2014.
4. P. D. Sethi, “HPTLC: High Performance Thin Layer Chromatography: Quantitative Analysis of Pharmaceutical Formulations”, 1st edition, CBS, 2013.
2. Hobert H. Willard, “Instrumental Methods of Analysis”, 7th Edition,CBS Publishers & Distributors, 2004.
3. B.K. Sharma, “Instrumental Method of Chemical Analysis”, Krishna’s Education Publishers, 2014.
4. P. D. Sethi, “HPTLC: High Performance Thin Layer Chromatography: Quantitative Analysis of Pharmaceutical Formulations”, 1st edition, CBS, 2013.
REFERENCES:
1. Robert M. Silverstein, Francis X .Webster , David J. Kiemle,David L. Bryce, cirtemortcepS“ identification of Organic Compounds”, 8th Edition, Wiley, 2014.
2. Mendham J, “Vogel’s Text Book of Quantitative Chemical Analysis”, 6th Edition, Pearson Education 2009.
3. Douglas A. Skoog, F. James Holler, Stanley R. Crouch, “Principles of Instrumental Analysis”, 7th Edition, Brooks Cole, 2017.
4. William Kemp, “Organic Spectroscopy” W.H. Freeman, New York, 3rd Edition, 2011.
2. Mendham J, “Vogel’s Text Book of Quantitative Chemical Analysis”, 6th Edition, Pearson Education 2009.
3. Douglas A. Skoog, F. James Holler, Stanley R. Crouch, “Principles of Instrumental Analysis”, 7th Edition, Brooks Cole, 2017.
4. William Kemp, “Organic Spectroscopy” W.H. Freeman, New York, 3rd Edition, 2011.
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