PY8501 - MEDICINAL CHEMISTRY (Syllabus) 2017-regulation Anna University

PY8501 - MEDICINAL CHEMISTRY (Syllabus) 2017-regulation Anna University

PY8501

MEDICINAL CHEMISTRY

 LPTC

3003

OBJECTIVES:
• To impart comprehensive understanding of the chemical basis of drug action including physicochemical and steric properties of drug.
• To study the classification, chemical nomenclature, generic names and synthesis of various medicinal agents.
• To understand the structure activity relationship, biochemical/molecular basis of mechanism of action and uses of drug.

UNIT I

PRINCIPLES OF MEDICINAL CHEMISTRY

12

Physicochemical properties in relation to biological action: Ionization, Drug distribution and pKa values and their relation to drug transport, hydrogen bonding, redox potential, surface activity and chelation. Steric properties of drugs: optical and geometrical isomerism. Functional group and their effects of on drug action: steric effect, concept of isosterism, bioisosterism, homologs and analogs.

UNIT II

DRUGS ACTING ON SYNAPTIC AND NEURO-EFFECTOR JUNCTION SITES

12

Classification, biochemical/molecular basis of mechanism of action, structure activity relationship including stereo chemical aspects, physiochemical properties and synthesis of selected drugs belonging to the class of Cholinergics, Anticholinergics, Anticholinesterases and Adrenergics.


UNIT III

DRUGS ACTING ON THE CENTRAL NERVOUS SYSTEM

12

Classification, molecular basis of mechanism of action, structure activity relationship and synthesis of Hypnotics and Sedatives, Opioid analgesics, Anticonvulsants and Psychopharmacological agents (neuroleptics, antidepressants, anxiolytics).

UNIT IV

DRUGS ACTING ON CARDIOVASCULAR SYSTEM

12

Structural basis of mechanism of action, structure activity relationship including physiochemical properties, and synthesis of selected drugs belonging to the class of anti-anginal, vasodilators, calcium channel blockers and cardiac glycosides.

UNIT V

AUTOCOIDS

12

Synthetic procedures, uses, structure activity relationship including physicochemical properties of the following classes of drugs Antihistamines, Eicosanoids, Analgesic-antipyretics, Anti - inflammatory (non-steroidal) agents

TOTAL : 60 PERIODS

OUTCOMES: The student will be able to
• Gain an appreciation of importance of the physical properties of drugs with respect to the ionization, solubility and efficacy of drugs, understand how changes in the chemical structure of drugs affect efficacy.
• Obtain a working knowledge of chemical structures and nomenclature, to develop the ability to suggest suitable techniques to synthesis different drug molecules.
• Understand how current drugs were developed and demonstrate the importance of chemistry in the development and application of therapeutic drugs.

TEXT BOOKS:
1. Ashutosh Kar, Medicinal Chemistry, 6th Edition, New Age International (P) Ltd. Publishers, New Delhi 2015.
2. Graham L. Patrick, An introduction to Medicinal Chemistry ,6th Edition, Oxford University Press, 2017.
3. Ilango, K. and Valentina, P., “Text book of Medicinal Chemistry”, Vol.1, 1st edition, Keerthi Publishers,2007.

REFERENCES:
1. Donald J. Abraham, Burger’s Medicinal Chemistry and Drug Discovery, Vol V, 6th Edition, John Wiley and Sons, Inc., 2003.
2. William O Foye, Thomas L Lemke, David A Williams Foye’s Principles of Medicinal Chemistry, 7th Edition, Wolters Kluwer Health Adis (ESP) Publisher, 2012.
3. Indian Pharmacopoeia, Vol-I,7th Edition, Published by Indian Pharmacopoeia Commission India, 2014.

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