PY8703 - CHEMISTRY OF NATURAL PRODUCTS (Syllabus) 2017-regulation Anna University

PY8703 - CHEMISTRY OF NATURAL PRODUCTS (Syllabus) 2017-regulation Anna University

PY8703

CHEMISTRY OF NATURAL PRODUCTS

 LPTC
3003

OBJECTIVE:
• To provide knowledge on isolation, characterization and biological significance of natural products and their active substances.

UNIT I

STRUCTURAL CHARACTERISATION OF NATURAL PRODUCTS

9
Chemical and spectral approaches to simple molecules of natural origin. Identification of natural products by chromatographic and spectroscopic methods and application of I.R., N.M.R. and Mass spectroscopy in the structural elucidation of organic compounds.

UNIT II

GLYCOSIDES

9
Classification, biosynthetic studies and basic metabolic pathways, introduction to biogenesis of secondary metabolites, chemistry, general methods of extraction, isolation, chemical tests, medicinal properties and structural elucidation of sennosides, cardenolides and bufadienolides, digoxin and digitoxin, scillaren A and ouabain.


UNIT III

ALKALOIDS

9
Classification, chemistry, general methods of extraction, isolation, chemical tests, and structural elucidation of pyridine alkaloids, tropane alkaloids, quinoline and iso-quinoline alkaloids, phenanthrene alkaloids, indole alkaloids, imidazole alkaloids, alkaloid amines, glycoalkaloids and xanthene alkaloids.

UNIT IV

TERPENES AND FLAVONOIDS

9
Classification, biosynthetic studies and basic metabolic pathways, introduction to biogenesis of secondary metabolites, chemistry, general methods of extraction, isolation, chemical tests, medicinal properties and structural elucidation of flavonoids, quercetin; Terpenes–special isoprene rule, mono, diterpenes, triterpenoids and sesquiterpenes and structural elucidation of citral, carvone, menthol and camphor; Steroids – cholesterol, colour reactions of steroids, stigmasterol, β-sitosterol, bile acids, ergosterol, diosgenin, solasodine and hecogenin.

UNIT V

PHARMACEUTICALLY IMPORTANT NATURAL PRODUCTS

9
Structure, stereochemistry, synthesis, biogenesis and biological activity of azadirachtin, forskolin, taxanes, camptothecin, artemisinin, podophyllotoxin, estrone and mifepristone.

TOTAL : 45 PERIODS

OUTCOMES:The students will be able
• To understand and apply the concept of extraction, isolation and characterization of the natural products.
• To explain the classification, metabolic pathways, metabolites and structural elucidation of plant secondary metabolites.
• To acquire knowledge on structure, synthesis, biogenesis and biological activity of some of the pharmaceutically important natural products.

TEXT BOOKS:
1. O.P. Agarwal, Chemistry of Natural Products (Vol.-1 & 2), 41st edition, GoelpublishingHouse, 2014.
2. Gurdeep Chatwal, Organic Chemistry of Natural Products (Vol. 1 & 2), Himalaya Publishing House, 2015.
3. I.L.Finar, “Organic chemistry” Volume 2, 5th edition, Published by Pearson India, 2012.

REFERENCES:
1. Varro E. Tyler, Lynn R. Brady, James E. Robbers, Pharmacognosy, 9th edition, Published by Lea & Febiger, 2011.
2. Trease, G. E. and Evans, W.C. Pharmacognosy, 16th edition, Published by Elsevier, 2009.
3. Wallis, T.E. Textbook of Pharmacognosy, 5th Edition, CBS Publishers, 2005.
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