BM3251 - BIOSCIENCES FOR MEDICAL ENGINEERING (Syllabus) 2021-regulation Anna University

BM3251 - BIOSCIENCES FOR MEDICAL ENGINEERING (Syllabus) 2021-regulation Anna University

BM3251	BIOSCIENCES FOR MEDICAL ENGINEERING	LPTC

3003

COURSE OBJECTIVES: The student should be:

• To study structural and functional properties of carbohydrates, proteins, lipids and amino acids
• To emphasize the role of these biomolecules by providing basic information on specific metabolic diseases and disorders of these biomolecules
• Gain knowledge on the structural and functional aspects of living organisms.
• Know the etiology and remedy in treating the pathological diseases.

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UNIT I	FUNDAMENTALS TO BIOCHEMISTRY	9

Introduction to Biochemistry, water as a biological solvent, weak acid and bases, pH, buffers, Handerson - Hasselbalch equation, physiological buffers in living systems, Energy in living organism. Properties of water and their applications in biological systems. Introduction to Biomolecules, Biological membrane, Clinical application of Electrolytes and radioisotopes.

UNIT II	CARBOHYDRATES, LIPIDS, PROTEIN	9

Classification of carbohydrates - mono, di, oligo and polysaccharides. Structure, physical and chemical properties of carbohydrates - Classification of lipids- simple, compound, and derived lipids. Nomenclature of fatty acid - Structure and properties of proteins, structural organization of proteins, classification and properties of amino acids. Nucleic acid: Structural aspects – Components of DNA and RNA, Nucleosides & Nucleotides (introduction, structure & bonding), Double helical structure of DNA (Watson-Crick model), various forms of DNA.

UNIT III	CELL DEGENERATION, REPAIR AND NEOPLASIA	9

Cell injury - Reversible cell injury and Irreversible cell injury and Necrosis, Apoptosis, Intracellular accumulations, Pathological calcification- Dystrophic and Metastatic. cellular adaptations of growth and differentiation, Inflammation and Repair including fracture healing, Neoplasia, Classification, Benign and Malignant tumours, carcinogenesis, spread of tumours Autopsy and biopsy.

UNIT IV	FLUID AND HEMODYNAMIC DERANGEMENTS	9

Edema, Hyperemia/Ischemia, normal hemostasis, thrombosis, disseminated intravascular coagulation, embolism, infarction, shock, Chronic venous congestion. Hematological disorders- Bleeding disorders, Leukaemias, Lymphomas Haemorrhage.

UNIT V	FUNDAMENTALS OF MICROBIOLOGY AND IMMUNOPATHOLOGY	9

Structure of Bacteria and Virus - Morphological features and structural organization of bacteria and virus - List of common bacterial, fungal and viral diseases of human beings.- Basics of Microscopes : Light microscope, Electron microscope (TEM & SEM). - Natural and artificial immunity, types of Hypersensitivity, antibody and cell mediated tissue injury, Immunological techniques: immune diffusion, immuno electrophoresis, RIA and ELISA, monoclonal antibodies.

TOTAL : 45 PERIODS

COURSE OUTCOMES: At the end of the course, the student should be able to:

• Explain the fundamentals of biochemistry
• Analyze structural and functional aspects of living organisms.
• Explain the function of microscope
• Describe methods involved in treating the pathological diseases.

TEXT BOOKS:

1. RAFI MD “Text book of biochemistry for Medical Student” Fourth Edition, Universities Press, Orient Blackswan Private Limited - New Delhi 2021.
2. Ramzi S Cotran, Vinay Kumar & Stanley L Robbins, “Pathologic Basis of Diseases”, 10th edition: South Asia Edition Elsevier India, 2020. (Units III & IV).
3. Ananthanarayanan & Panicker, “Microbiology” Orientblackswan, 2017 10th edition. (Units III,IV and V).

REFERENCES:

1. Keith Wilson & John Walker, “Practical Biochemistry - Principles & Techniques”, Oxford University Press, 2009.
2. Underwood JCE: General and Systematic Pathology Churchill Livingstone, 3rd edition, 2000.
3. Dubey RC and Maheswari DK. “A Text Book of Microbiology” Chand & Company Ltd, 2007
4. Prescott, Harley and Klein, “Microbiology”, 10th edition, McGraw Hill, 2017