BT3201 - BIOORGANIC CHEMISTRY (Syllabus) 2021-regulation Anna University

BT3201 - BIOORGANIC CHEMISTRY (Syllabus) 2021-regulation Anna University

BT3201 BIOORGANIC CHEMISTRY  LPTC
3003

COURSE OBJECTIVES
• Enable the students to understand the basics concepts of chemical reactions
• Make students understand the kinetics and its reaction mechanism.

UNIT I BONDING AND STEREOCHEMISTRY 9
Atoms Electrons and orbitals - Covalent Bonds - Octet rule - Polar covalent Bonds - Electronegativity- formal charge - Resonance Acids and Bases - Arrhenius and Bronsted Lowry Theories - Acid Base equilibria - SP3 hybridization – Conformation analysis ethane, butane and cyclohexane - Cis- trans isomerism. Stereochemical activity around the tetrahedral carbon – optical activity - Conformation of the peptide bond.

UNIT II MECHANISMS OF SUBSTITUTION AND ADDITION REACTIONS 9
SN1 and SN2 reactions on tetrahedral carbon- nucleophiles- mechanism steric effects – nucleophilic addition on Acetals and ketals -Aldehyde and ketone groups – reactions of carbonyl group with amines- acid catalyzed ester hydrolysis – Saponification of an ester- hydrolysis of amides. Ester enolates - claisen condensation – Michael condensation.


UNIT III KINETICS AND MECHANISM 9
Kinetic method – Rate law and mechanism – Transition states- Intermediates – Trapping of intermediates – Microscopic reversibility – Kinetic and thermodynamic reversibility – Isotopes for detecting intermediates. Primary and secondary isotopes – the Arrhenius equation Eyring equation - ΔG, ΔS, ΔH, Thermodynamics of coupled reactions.

UNIT IV CATALYSIS 9
Reactivity – Coenzymes – Proton transfer – metal ions – Intra molecular reactions – Covalent catalysis – Catalysis by organized aggregates and phases. Inclusion complexation

UNIT V BIOORGANIC REACTIONS 9
Timing of Bond formation and fission – Acyl group transfer – C-C bond formation and fission – Catalysis of proton transfer reactions – Transfer of hydride ion – Alkyl group. Transfer – Terpene biosynthesis – Merrifield state peptide synthesis – Sanger method for peptide and DNA sequencing

TOTAL : 45 PERIODS

COURSE OUTCOMES: At the end of the course the students will be able to
CO1 : bonding and stereochemistr
CO2 : mechanisms of substitution and addition reactions CO3 : Thermodynamics, kinetics and mechanism
CO4 : Catalysis
CO5 : Bioorganic reactions and mechanisms

TEXT BOOKS:
1. Carey, Francis A.” Organic Chemistry”. VIIth Edition, Tata McGraw Hill, 2009.
2. Page, M.I. and Andrew Williams “Organic and Bio-organic Mechanisms”. Pearson, 2010.

REFERENCES:
1. Dugas, Hermann “Bioorganic Chemistry: A Chemical Approach to Enzyme Action” 3rd Edition, Springer, 2003
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