PH3252 - MATERIALS SCIENCE FOR BIOTECHNOLOGISTS (Syllabus) 2021-regulation Anna University

PH3252 - MATERIALS SCIENCE FOR BIOTECHNOLOGISTS (Syllabus) 2021-regulation Anna University

PH3252

MATERIALS SCIENCE FOR BIOTECHNOLOGISTS

 LPTC

3003

OBJECTIVES:
• To make the students effectively to understand the basics of crystallography and crystal imperfections.
• To enable the students to get knowledge on various strengthening methods of materials, and also various mechanical ties and the r measurement.
• To impart knowledge on the basics of phase diagrams and their applications.
• To learn about iron-carbon system, and about various ferrous and non-ferrous alloys.
• To introduce different types of biomaterials and their applications.

UNIT I

CRYSTALLOGRAPHY

9

Crystallographic directions and planes – metallic crystal structures: BCC, FCC and HCP – linear and planar densities – crystal imperfections- edge and screw dislocations, Burgers vector and elastic strain energy- surface imperfections – grain and twin boundaries – Polymorphism – phase changes – nucleation and growth – homogeneous and heterogeneous nucleation.

UNIT II

MECHANICAL PROPERTIES

9

Tensile test - plastic deformation by slip – slip systems – mechanisms of strengthening in metals: strain hardening, grain size reduction, solid solution strengthening, precipitation hardening – Creep: creep curves,stress and temperature effects, mechanisms of creep, creep-resistant materials – Fracture: ductile and brittle fractures - the Griffith criterion –fracture toughness - Fatigue failure:the S-N curve – factors that affect fatigue life – Hardness: Rockwell and Brinell hardness tests, Knoop and Vickers microhardness tests.


UNIT III

PHASE DIAGRAMS

9

Basic concepts - Gibbs phase rule –Unary phase diagram (iron) - Binary phase diagrams: isomorphous systems (Cu-Ni) –determination of phase composition and phase amounts – tieline and lever rule - binary eutectic diagram with no solid solution and limited solid solution (Pb-Sn) – eutectoid and peritectic reactions - other invariant reactions – microstructural development during the slow cooling: eutectic, hypereutectic and hypoeutectic compositions.

UNIT IV

FERROUS AND NONFERROUS ALLOYS

9

The Fe-Fe3C phase diagram: phases, invariant reactions,development of microstructure in eutectoid, hypoeutectoid and hypereutectoid alloys–influence of other alloying elements in the Fe- C system - phase transformations –isothermal transformation diagram for eutectoid iron-carbon alloy – microstructures: pearlite, bainite, spheroidite and martensite – steels, stainless steels and cast irons – copper alloys – aluminum alloys – titanium alloys.

UNIT V

MATERIALS FOR BIOLOGICAL APPLICATIONS

9

Biocompatibility – host response – materials response – Metallic implants: Titanium and its alloys, stainless steel – Cobalt-Chromium alloys – Tantalum – Nitinol – magnesium based biodegradable alloys. Bioceramics: Alumina, Zirconia, hydroxyapatite, tricalcium phosphate, bioactive glasses, pyrolytic carbon, graphite, graphene. Polymeric implant materials: Polyethylene, polypropylene, polyacrylates – soft and hard tissue replacement materials.

TOTAL : 45 PERIODS

OUTCOMES: Upon completion of this course, the students should be able to
• understand the basics of crystallography and its importance in materials properties
• understand the significance of dislocations, strengthening mechanisms, and tensile, creep, hardness and fracture behavior of materials
• gain knowledge on binary phase diagrams, and also will be able to determine the phase composition and phase amount.
• understand about the Fe-C system and various microstructures in it, and also about various ferrous and non-ferrous alloys.
• get adequate understanding on metallic, ceramic and polymeric biomaterials and their applications.

TEXT BOOKS:
1. R.Balasubramaniam, Calli er’s Materials Science and Engineering.Wiley (Indian Edition), 2014.
2. V.Raghavan. Materials Science and Engineering: A First Course, Prentice Hall India Learning Private Limited, 2015.
3. Joon Park and R.S.Lakes, Biomaterials: An Introduction, Springer, 2007.

REFERENCES:
1. J.F.Shackelford. Introduction to Materials Science for Engineers. Pearson, 2015.
2. Wendelin Wri ht and Donald Askeland, Essentials of Materials Science and Engineering, CL Engineering, 2013.
3. J.C. Anderson, K.D. Leaver, P. Leevers and R.D. Rawlings, Materials Science for Engineers, CRC Press, 2003.
4. Jean P.Mercier, G.Zambelli and W.Kurz, Introduction to Materials Science, Elsevier, 2002.
5. Sujata V.Bhat, Biomaterials, Narosa Publishers, 2002.

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