BT8021 - GENETICS (Syllabus) 2017-regulation Anna University

BT8021 - GENETICS (Syllabus) 2017-regulation Anna University

BT8021	GENETICS	LPTC

3003

AIM:

• To give an understanding on the fundamentals of conventional genetics and its relevance in disease and therapy

OBJECTIVES:

• To describe various genetic laws, learn the chromosome structure function and understand methodologies for cytogenetic applications

UNIT I	BACTERIAL GENETICS	9

Transformation, Transduction, Conjugation – mapping, fine structure mapping in merozygotes- plasmids and episomes

UNIT II	CLASSICAL GENETICS	9

Mendel’s principles and experiments, segregation, multiple alleles – Independent Assortments, Genotypic interactions, epistasis and Sex chromosomes, Sex determination, Dosage compensation, sex linkage and pedigree analysis

UNIT III	APPLIED GENETICS	9

Chromosome organization, structure and variation in prokaryotes and eukaryotes, Giant chromosomes – polytene and lampbrush, deletion, inversion, translocation, duplication. variation in chromosomal numbers – aneuploidy, euploidy, polyploidy, Ames test, karyotyping, Linkage, Crossing over – cytological basis of crossing over, chromosome mapping – two and three factor cross – interference, somatic cell hybridization

UNIT IV	POPULATION GENETICS	9

Hardy-Weinberg equilibrium, Extensions of Hardy- Weinberg equilibrium, non random mating, population analysis, Models for population genetics. Mutation and Migration size, Genetic variation and Sociobiology

UNIT V	GENETIC DISEASES	9

Inborn errors of metabolism, Sickle cell, hemochromatosis, cystic fibrosis, hypogonadotropic hypogonadism, Gaucher’s disease, achondroplasia, phenylketonuria, Huntington’s Disease, Cystic fibrosis, hemoglobinopathies, Age-related macular degeneration, Obesity, Type 2 diabetes, Psychiatric disease, including missing heritability, autism

TOTAL : 45 PERIODS

TEXT BOOKS:

1. Tamarin, R.H., “Principles of Genetics”, Tata McGraw Hill, New Delhi, 2002
2. De Robertis, E. D. P. and De Robertis, E. M. F., “Cell and Molecular Biology”, 8th Edition,Lippincott Williams & Wilkins, New York, USA, 2001.

REFERENCES:

1. Gardner, E.J, Simmons, M.J, and Snustad, D.P., “Principles of Genetics”,8th Edition, JohnWiley & Sons, Singapore, 2003.
2. Strickberger, M.W., “Genetics”, 3rd Edition, Prentice Hall of India, New Delhi, 2008.
3. Klug, W.S. and Cummings, M.R., “Concepts of Genetics”, Pearson Education, New Delhi, 2003.