PY6011 - INTRODUCTION TO BIOMATERIALS AND TISSUE ENGINEERING (Syllabus) 2013-regulation Anna University

PY6011 - INTRODUCTION TO BIOMATERIALS AND TISSUE ENGINEERING (Syllabus) 2013-regulation Anna University

PY6011	INTRODUCTION TO BIOMATERIALS AND TISSUE ENGINEERING	LPTC

3003

OBJECTIVES:

• To understand the basics and properties of biomaterials.
• To study the clinical applications of biomaterials in tissue engineering.

UNIT I	INTRODUCTION	9

Introduction to tissue engineering: Basic definition; current scope of development; use in therapeutics, cells as therapeutic agents, cell numbers and growth rates, measurement of cell characteristics morphology, number viability, motility and functions. Measurement of tissue characteristics, appearance, cellular component, ECM component, mechanical measurements and physical properties.

UNIT II	TISSUE ARCHITECTURE	9

Tissue types and Tissue components, Tissue repair, Engineering wound healing and sequence of events. Basic wound healing Applications of growth factors: VEGF/angiogenesis, Basic properties, Cell-Matrix & Cell-Cell Interactions, telomeres and Self-renewal, Control of cell migration in tissue engineering.

UNIT III	BIOMATERIALS	9

Biomaterials: Properties of biomaterials, Surface, bulk, mechanical and biological properties. Scaffolds & tissue engineering, Types of biomaterials, biological and synthetic materials, Biopolymers, Applications of biomaterials, Modifications of Biomaterials, Role of Nanotechnology.

UNIT IV	BASIC BIOLOGY OF STEM CELLS	9

Stem Cells : Introduction, hematopoietic differentiation pathway Potency and plasticity of stem cells, sources, embryonic stem cells, hematopoietic and mesenchymal stem cells, Stem Cell markers, FACS analysis, Differentiation, Stem cell systems- Liver, neuronal stem cells, Types & sources of stem cell with characteristics: embryonic, adult, haematopoetic, fetal, cord blood, placenta, bone marrow, primordial germ cells, cancer stem cells induced pleuripotent stem cells.

UNIT V	CLINICAL APPLICATIONS	9

Stem cell therapy, Molecular therapy, In vitro organogenesis, Neurodegenrative diseases, spinal cord injury, heart disease, diabetes, burns and skin ulcers, muscular dystrophy, orthopedic applications, Stem cells and Gene therapy Physiological models, tissue engineered therapies, product characterization, components, safety, efficacy. Preservation–freezing and drying. Patent protection and regulation of tissue-engineered products, ethical issues.

TOTAL : 45 PERIODS

OUTCOMES: The student will be able to

• Understand the basics characters and current developments in biomaterials.
• Understand the tissue types, tissue components, tissue repairing techniques and wound healing sequence for the tissue architecture.
• Understand the various types, sources of stem cells with characteristics and the potency, plasticity of stem cells.
• Understand the major clinical applications (spinal cord injury, heart disease, orthopedic applications etc.) of stem cell therapy.

TEXT BOOKS:

1. Bernhard O.Palsson,Sangeeta N.Bhatia,”Tissue Engineering” Pearson Publishers 2009.
2. Meyer, U.; Meyer, Th.; Handschel, J.; Wiesmann, H.P. Fundamentals of Tissue Engineering and Regenerative Medicine.2009.

REFERENCES:

1. Bernard N. Kennedy (editor). New York : Nova Science Publishers, 2008.Stem cell transplantation, tissue engineering, and cancer applications
2. Raphael Gorodetsky, Richard Schäfer. Cambridge : RSC Publishing, c2011. Stem cell based tissue repair.
3. R. Lanza, J. Gearhart etal (Eds), Essential of Stem Cell Biology, 2006, Elsevier Academic press.