BT8007 - CANCER BIOLOGY (Syllabus) 2017-regulation Anna University

BT8007 - CANCER BIOLOGY (Syllabus) 2017-regulation Anna University

BT8007

CANCER BIOLOGY

 LPTC
3003

OBJECTIVES:
To enable the students to understand • Basic biology of cancer • Impact of antibodies against cancer in the human body leading to more effective treatments • Enhanced immunology based detection methods and imaging techniques • Development of cell based and cytokine based immunotherapy against cancer.

UNIT I

FUNDAMENTALS OF CANCER BIOLOGY

9
Regulation of cell cycle, mutations that cause changes in signal molecules, effects on receptor, signal switches, tumour suppressor genes, modulation of cell cycle in cancer, different forms of cancers, diet and cancer. Cancer screening and early detection, Detection using biochemical assays, tumor markers, molecular tools for early diagnosis of cancer.

UNIT II

PRINCIPLES OF CARCINOGENESIS

9
Theory of carcinogenesis, Chemical carcinogenesis, metabolism of carcinogenesis, principles of physical carcinogenesis, x-ray radiation-mechanisms of radiation carcinogenesis.


UNIT III

PRINCIPLES OF MOLECULAR CELL BIOLOGY OF CANCER

9
Signal targets and cancer, activation of kinases; Oncogenes, identification of oncogenes, retroviruses and oncogenes, detection of oncogenes. Oncogenes/proto oncogene activity. Growth factors related to transformation. Telomerases.

UNIT IV

PRINCIPLES OF CANCER METASTASIS

9
Clinical significances of invasion, heterogeneity of metastatic phenotype, metastatic cascade, basement membrane disruption, three step theory of invasion, proteinases and tumour cell invasion.

UNIT V

NEW MOLECULES FOR CANCER THERAPY

9
Different forms of therapy, chemotherapy, radiation therapy, detection of cancers, prediction of aggressiveness of cancer, advances in cancer detection. Use of signal targets towards therapy of cancer; Gene therapy.

TOTAL : 45 PERIODS

OUTCOMES: The course would facilitate the students
• To appreciate the role of immune system in cancer • To describe self – tolerance machinery and immune surveillance • To understand the cancer microenvironment and its influence on immune cells • To have awareness on medical applications of cytokines and immune cells against cancer

TEXT BOOKS:
1. Weinberg, R.A. “The Biology of Cancer” Garland Science, 2007
2. McDonald, F etal., “ Molecular Biology of Cancer” IInd Edition. Taylor & Francis, 2004.

REFERENCES:
1. King, Roger J.B. “Cancer Biology” Addison Wesley Longman, 1996. 2. Ruddon, Raymond W. “ Cancer Biology” IIIrd Edition . Oxford University Press, 1995.
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